Clinical Case Scenario 1

A 72-year-old man is hospitalized for respiratory failure caused by pneumonia acquired in the community. Blood cultures confirm pneumococcal infection. He receives appropriate antibiotics but requires intubation due to worsening hypotension despite IV fluids. Norepinephrine and vasopressin are initiated to manage the worsening hypotension. Over the next 72 hours, his creatinine levels elevate from 1.0 to 4.6 mg/dl, and his urine output decreases to 0–5 mL/hr. A family conference is scheduled to discuss the potential need for continuous renal replacement therapy (CRRT).

Which of the following statements is the most accurate?