Clinical Case Scenario
A 16-year-old male with a history of type 1 diabetes mellitus presented in the emergency department. His condition has worsened over the past 3 days. He reported extreme thirst and has been drinking large quantities of fluids and juice. His urine output was very high during this period, and on history taking, it was found out that he had not been compliant with his insulin regimen for the last month. His urine flow rate is measured at 12 mL/min in the emergency room using a uroflowmeter.
Despite excreting large quantities of glucose in the urine, her plasma glucose concentration remains unchanged over the observation period.
What is the primary mechanism responsible for this patient’s polyuria?
