Clinical Case Scenario

A 16-year-old girl is anaesthetized for scoliosis surgery. After induction of anaesthesia, the patient, who is under anaesthesia with isoflurane and nitrous oxide, suddenly develops unexplained tachycardia, a high end-tidal CO2 (EtCO2) of 54 mmHg, and a fever of 39°C.

The anaesthesia team administers an initial bolus of dantrolene sodium at 1 mg/kg. Despite this treatment, the patient's tachycardia and elevated EtCO2 levels do not improve. She is then transferred to the intensive care unit (ICU).

What is the most appropriate next step in the management of this patient while in the ICU?