Clinical Case Scenario
A 50-year-old female with a history of acute myeloid leukemia (AML) was critically ill and developed a urinary tract infection caused by vancomycin-resistant Enterococcus faecium (VRE), which progressed to urosepsis. The patient had previously experienced prolonged hospitalization and had received broad-spectrum antibiotics. Initial laboratory tests revealed severe thrombocytopenia, with platelet levels measured at 20,000/µL. Due to the VRE infection, the patient was started on daptomycin therapy.
Clinical Progression Within Three Days
- Creatine kinase (CK) levels increased significantly, reaching 1,000 U/L.
- Serum potassium levels rose to 5.7 mmol/L.
What is the most likely mechanism of this toxicity?
